Epigenetic regulation of genome integrity by a prion-based mechanism
Byers, J.S., Garcia, D.M., Jarosz, D.F.
Revealed how a newly discovered non-amyloid prion can fuel a quasi-Lamarckian form of inheritance that promotes survival of the current generation and diversification of the next.
A common bacterial metabolite elicits prion-based bypass of glucose repression
Garcia, D.M.*, Dietrich, D.*, Clardy, J.‡, Jarosz, D.F.‡
Activity-guided fractionation identified the first bacterial metabolite that potently induces a prion in nature. Demonstrated that chemically simple and ubiquitous small molecules can induce epigenetic states. Also finally explained a mysterious observation first made by Louis Pasteur over 140 years ago.
• eLife Insight: An acid tale of prion formation. Tuite, M.F., eLife 2016, 5:e22256
• Editor’s Choice: Bacteria stop fermentation with lactic acid. Science Signaling 9,457: ec288
• Stanford Medicine Scope: How prions help yeast feast. Spector, R., December 1, 2016
Intrinsically Disordered Proteins Drive Emergence and Inheritance of Biological Traits
Chakrabortee, S.*, Byers, J.S.*, Jones, S., Garcia, D.M., Bhullar, B., Chang, A., She, R., Lee, L., Fremin, B., Lindquist, S. ‡, Jarosz, D.F. ‡
Defined a new class of non-amyloid prions in yeast responsible for protein-based transgenerational inheritance that do not rely necessarily on stable protein aggregates like classic (amyloid) prions.
• Remembering the Past: A New Form of Protein-Based Inheritance. Tuite, M.F., Cell 167, 369–381
• Science Daily: Revising the meaning of ‘prion’. October 4, 2016
• Stanford Medicine Scope: DNA dethroned? Spector, R., October 6, 2016
Weak Seed-Pairing Stability and High Target-Site Abundance Decrease the Proficiency of lsy-6 and Other miRNAs
Garcia, D.M.*, Baek, D.*, Shin, C., Bell, G.W., Grimson, A., Bartel, D.P.
Discovered new sequence features central to the microRNA pathway, an ancient and widespread mechanism of post-transcriptional gene control. Results were integrated into miRNA target prediction program TargetScan.org, used by tens of thousands of users per month.
science writing for the public
OZY magazine, 2014
Highlights research on planaria, nature's king of regeneration.
Great Adaptations: A versatile bacterium provides insight into multicellular microbial life and tackling deadly infections
Natural History Magazine, 2012
Story of how evolution constructs beautifully fluid connections between ancient microbiology and human disease.
Garcia, D.M. (plus contributors from MIT Biology)
The original online journal club. A blog about RNA research and biomedical science. ~50,000 views. (Active 2009–2015)