The Garcia Lab studies RNA chemical modifications, as well as the functions of the RNA-modifying enzymes that catalyze them, including their potential involvement in epigenetic control of cell growth. A recent focus has been advancement of direct RNA-sequencing technology, and other sequencing methods, to profile a variety of RNA modifications in vivo, particularly those on transfer RNA (tRNA). We work primarily in the model eukaryote S. cerevisiae (budding yeast). We collaborate closely with labs both at the University of Oregon and outside.
See PAPERS for our most recent pre-printed/published work. We are also a proud participant of the Oregon RNA Club.
We are grateful to these organizations for supporting our research: National Institutes of Health (NIH)/National Human Genome Research Institute (NHGRI)/National Institute of General Medical Sciences (NIGMS), The Donald E. and Delia B. Baxter Foundation, The Medical Research Foundation of Oregon, The University of Washington Nathan Shock Center of Excellence in the Basic Biology of Aging, and the University of Oregon 🦆